Work

Nano-TiO2 regulates the MAPK (ERK, P38) pathway to promote apoptosis and inhibit proliferation of human colon cells

Year: 2024

Type: article

Abstract: BACKGROUND: in vivo and in vitro, the underlying molecular mechanisms have not been fully revealed. METHODS: -NPs) on cell proliferation and apoptosis. The potential molecular mechanisms underlying its toxic effects were investigated through transcriptome analysis, RT-qPCR, and western blot experiments. RESULTS: -NPs (30-60 μg/mL) could up-regulate the expression of P53, P21 and Bax, while down-regulating the expression of Bcl2 by regulating the MAPK (ERK, P38) signaling pathway. Simultaneously, it also promoted the decreased in Fos protein expression and inhibited the phosphorylation of Jun and Fos. CONCLUSION: -NPs should be strictly regulated in practical applications.

Source: Ecotoxicology and Environmental Safety

DOI: 10.1016/j.ecoenv.2024.116973

Authors: Zhigang Xiao, Mingchuan Zheng, Jing Deng, Yi Shi, Mingxi Jia, Wen Li

Institutions: Hunan Normal University, Hunan Provincial People's Hospital, Central South University of Forestry and Technology, Xinjiang Agricultural University

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,990