Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores
Year: 2024
Type: article
Abstract: BACKGROUND: Eating disorder (ED) symptoms are prevalent in the general population, but their shared genetic underpinnings with psychiatric, metabolic, and anthropometric traits are not known. Here, we examined if polygenic scores (PGSs) of traits associated with anorexia nervosa are also associated with adolescent ED symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC). METHODS: A total of 8654 participants with genotype data and at least one phenotypic measure were included from the ALSPAC study. We associated PGS from 25 traits (16 psychiatric, 4 metabolic, and 5 anthropometric) with eight ED symptoms, including behaviours such as fasting for weight loss and cognitions such as body dissatisfaction. RESULTS: Higher attention deficit hyperactivity disorder PGS and lower educational attainment PGS were associated with fasting for weight loss. Higher insomnia PGS was associated with increased body dissatisfaction. We found no evidence of an association between metabolic trait PGS and any ED symptom. Fat-free mass, fat mass, and body fat percentage PGSs, were positively associated with binge eating, excessive exercise, fasting for weight loss, body dissatisfaction, and weight and shape concern. CONCLUSIONS: ED symptoms are genetically associated with psychiatric and anthropometric, but not with metabolic traits. Our findings provide insights for future genetic research investigating on why some individuals with ED symptoms progress to develop threshold EDs while others do not.
DOI: 10.17615/h2j8-8q70
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Funders: Brain and Behavior Research Foundation, Melanoma Research Foundation, Migraine Research Foundation, Wellcome Trust, National Institute for Health and Care Research, Department of Health and Social Care, University of Bristol, Lundbeckfonden, Vetenskapsrådet, H. Lundbeck A/S, National Institutes of Health, Arts and Humanities Research Council, Medical Research Council, National Institute of Mental Health
Awards: G103800658, G1181994271, G1375331873, Eating Disorders Genetics Initiative (EDGI), G1684393010, G1793884970, G211885902, G2953470886, G303339423, G3197369316, G3507283293, The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi- generation, longitudinal resource focusing on life course health and well- being., G395765120, G3964009410, G3987754321, G4034426326, Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems Approach, G4670273794, G4782823791, G5012122282, G5162486390, G5197328387, G5313676757, G5429586119, Premorbid metabolism and growth in anorexia nervosa: A genetically informed exploration of risk, G6652368163, The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways, G712881263, G7679553617, Predicting the multi-omic impact of psychiatric GWAS associations, The power of the environment: Environmental mediation of genetic liability, G8069300346, 1/7 Psychiatric Genomics Consortium: Finding actionable variation, G9000181952, G9000182571
OpenAlex ID: W4402028803