Work

Cu-Catalyzed Asymmetric Synthesis of γ-Amino Alcohols Featuring Tertiary Carbon Stereocenters

Year: 2024

Type: article

Abstract: Alkyne-functionalized oxetanes are presented as versatile substrates that in combination with amine reagents can be transformed into structurally diverse, chiral γ-amino alcohols featuring a tetrasubstituted tertiary stereocenter under Cu catalysis. Control experiments demonstrate the privileged nature of these oxetane precursors in terms of yield and asymmetric induction levels in the developed protocol, and postsynthetic modifications offer an easy way to access more advanced synthons.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c02682

Authors: Alejandro Delgado, Paolo Orlando, Matteo Lanzi, Jordi Benet-Buchholz, Daniele Passarella, Arjan W. Kleij