Photodynamic action on Escherichia coli of natural acetylenic thiophenes, particularly 5-(buten-1-ynyl)-2,2'-bithienyl
Year: 1983
Type: article
Abstract: Naturally occurring acetylenic photosensitizers, including a-terthienyl, 5-(4-hydroxy-l-butenyl)-2,2'-bithienyl, 5-(4-acetoxy-l-butenyl)-2,2'-bithienyl, and 5-(buten-3-ynyl)-2,2'-bithienyl, from species of Tagetes displayed photodynamic killing of Escherichia coli , Pseudomonas aeruginosa and the yeast, Saccharomyces cerevisiae in near UV light. The last compound affected rec mutant strains of E. coli to varying degrees suggesting that cellular DNA may be a molecular target for the photoactivated process. This is in contrast to α -terthienyl for which cellular membranes have been shown to be primary targets.
Authors: K.R. Downum, R.E.W. Hancock, G.H.N. Towers
Institution: University of British Columbia
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4402036613