Work

Biomarkers of intestinal permeability are associated with inflammation in metabolically healthy obesity but not normal-weight obesity

Year: 2024

Type: article

Study design: Observational Study

Abstract: This is the first study to our knowledge to examine biomarkers of intestinal permeability in normal-weight obesity and one of few assessing microbiota compositions in this population. Additionally, we report that individuals with metabolically healthy obesity and metabolically unhealthy obesity displayed similar evidence of intestinal permeability, which was more strongly associated with systemic inflammation than total and visceral adipose tissue mass.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00381.2024

Authors: Bryant H. Keirns, Austin R. Medlin, Katherine A. Maki, Kristen McClanahan, Sarah E. Fruit, Christina M. Sciarrillo, Samantha M. Hart, Jill Joyce, Edralin A. Lucas, Sam R. Emerson

Institutions: Ball State University, Indiana University Bloomington, Indiana University, National Institutes of Health, National Institutes of Health Clinical Center, Oklahoma State University, Oklahoma State University at Tulsa

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health, American Society for Nutrition

Award: Gut Permeability-related Inflammation and Cardiovascular Disease Risk in Normal-Weight and Metabolically Healthy Obesity

OpenAlex ID: W4402046038

FWCI: 1.277

Cites: 65

Cited by: 11

Related to: 10