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One day of environment-induced heat stress damages the murine myocardium

Year: 2024

Type: article

Abstract: The consequences of prolonged environment-induced heat stress (EIHS) on heart health are largely unknown. We discovered that a 24-h exposure to environmental conditions sufficient to cause EIHS resulted in cardiac edema and histopathologic changes in the right and left ventricles. Furthermore, among other biochemical changes, EIHS increased autophagic flux and caused endoplasmic reticulum stress. These data raise the possibility that thermic injury, even when insufficient to cause heat stroke, can damage the myocardium.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00180.2024

Authors: Melissa Roths, Tori E. Rudolph, Swathy Krishna, Alyona Michael, Joshua T. Selsby

Institutions: Iowa State University, Auburn University

Language: English

Topic: Thermoregulation and physiological responses

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: U.S. Department of Agriculture