Detection of anti-bacterial activity of silver nanoparticles from actinomycetes and testing its efficacy
Year: 2024
Type: article
Abstract: Silver nanoparticles rank among the most promising metal nanoparticles that are less than 100 nm in diameter. Their compact dimensions and substantial surface area-to-volume ratio lend them distinct physical, chemical, and biological properties that make them appealing for a multitude of applications. They can be synthesized in a variety of physical, chemical, and biological methods, and one such technique is the green route synthesis of AgNPs from actinomycetes. While AgNPs have immense potential in a diverse range of applications, its bactericidal effect is the focus of this current work. AgNPs' antibacterial activity was evaluated in both gram-positive and gram-negative bacteria at concentrations ranging from 25 to 150 μg. The bactericidal effect was more pronounced in gram-negative bacteria when compared to gram-positive bacteria. They exhibit twin actions of bactericidal assault and membrane rupture, which enable them to induce cell lysis and interfere with bacterial protein synthesis. Often alluded to as "Nano-antibiotics," these compounds may also serve as delivery systems for conventional antibiotics.
Authors: G. Selambarasi, P. Anusuya, Ananda Vayaravel Cassinadane
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4402051995