Year: 2024
Type: article
Abstract: A chemical investigation of the extracts from the soft coral Litophyton brassicum led to the isolation and identification of four new meroterpenes, brassihydroxybenzoquinone A and B (1 and 2) and brassinaphthoquinone A and B (3 and 4), along with two known related meroterpenes (5 and 6). Their structures were elucidated using high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR) spectroscopy, and a comparison with the literature data. All compounds were evaluated for antibacterial activity against six pathogenic bacterial strains and for cytotoxic activity against three cancer cell lines. In the cytotoxic assay, all compounds were inactive at 10 μM against the A549, HeLa, and MDA-MB-231 cell lines. In the antibacterial assay, compounds 1 and 2 exhibited moderate inhibitory activity with minimum inhibitory concentrations (MIC) ranging from 8 to 64 μg/mL.
Source: Marine Drugs
DOI: 10.3390/md22090392
Authors: Xiaoyi Chen, Jiahui Zhang, Jiayu Yang, Bing Li, Te Li, Han Ouyang, Wenhan Lin, Hongyu Hu, Xia Yan, Shan He
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,296
Funders: Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund, Chinese Academy of Sciences, Ningbo University, Higher Education Discipline Innovation Project, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Institute of Oceanology, Chinese Academy of Sciences
Awards: G684463329, G8051799436, G8965395033
OpenAlex ID: W4402052275