Synthesis, Characterization and Antibacterial Screening of Some Novel Compounds containing Multi N-Fused Heterocycles
Year: 2024
Type: article
Abstract: An attempt has been made to synthesize novel multi N-fused heterocyclic compounds containing four divergent heterocyclic compounds such as imidazole, pyrimidine, morpholine and indole. A series of N-(4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-yl)-2-(4-((E)-3-(2-morpholino-9H-pyrido[2,3-b]indol-3-yl)acryloyl)phenylamino)acetamide (6a-c) was accomplished in good yields with 1-(1H-benzo-[d]imidazol-2-yl)ethanone (1) as starting compound and through the formation of (E)-1-(1H-benzo[d]imidazol-2-yl)-3-phenylprop-2-ne-1-ones (2a-c), 4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-amines (3a-c) and N-(4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-yl)-2-chloroacetamides (4a-c) as intermediates on extension of the reaction. The structural elucidation of all the synthesized compounds were characterized by IR, 1H NMR, mass spectral data and elemental analysis. Further, the title compounds were also used to evaluate their antibacterial activity.
Source: Asian Journal of Chemistry
Authors: J. Udaya Bhaskar, G. Srinivasa Rao, Pranab Chatterjee, D.K. Sahoo, S. Srinivasa Rao, B. Pulla Rao
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4402055856