Work

Subunit-Specific Developmental Roles of PI3K in SF1-Expressing Cells

Year: 2024

Type: article

Abstract: BACKGRUOUND: Phosphatidylinositol 3-kinase (PI3K) regulates cellular development and energy homeostasis. However, the roles of its subunits in organ development remain largely unknown. METHODS: We explored the roles of PI3K catalytic subunits in steroidogenic factor 1 (SF1)-expressing cells through knockout (KO) of the p110α and p110β subunits. RESULTS: We examined mice with a double KO of p110α and p110β in SF1-expressing cells (p110αβ KOSF1). Although these animals exhibited no significant changes in the development of the ventromedial hypothalamus, we noted pronounced hypotrophy in the adrenal cortex, testis, and ovary. Additionally, corticosterone and aldosterone levels were significantly reduced. The absence of these subunits also resulted in decreased body weight and survival rate, along with impaired glucose homeostasis, in p110αβ KOSF1 mice. CONCLUSION: The data demonstrate the specific roles of PI3K catalytic subunits in the development and function of SF1-expressing organs.

Source: Endocrinology and Metabolism

DOI: 10.3803/enm.2024.1999

Authors: My Khanh Q. Huynh, Sang Hee Lyoo, Dong Joo Yang, Yun-Hee Choi, Ki Woo Kim

Institutions: Yonsei University, Yonsei University College of Dentistry

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Yonsei University, Yonsei University College of Dentistry