Work

Two protein‐derived peptides from Bombyx mori attenuate colitis by enhancing intestinal barrier function and modulating gut microbiota ecology

Year: 2024

Type: article

Abstract: Food‐sourced proteins have been shown to have ameliorative effects on ulcerative colitis (UC), and studies have identified potential anti‐inflammatory activity of silkworm pupa proteins. Here, we identified and screened two novel protein‐derived peptides, PDLGLF (PD‐6) and GTEGGFPF (GT‐8), from Bombyx mori using UPLC–MS/MS and bioinformatics analysis. These peptides can serve as effective experimental drugs for colitis by modulating the gut microbiota. Treatment with peptides PD‐6 and GT‐8 inhibited colitis inflammation in UC mice, improved oxidative stress levels, and maintained intestinal epithelial barrier function. Peptides PD‐6 and GT‐8 also altered the diversity and composition of the gut microbiota in UC mice and increased the concentration of short‐chain fatty acids. In conclusion, these findings reveal the potential of the naturally derived bioactive peptides PD‐6 and GT‐8 in controlling intestinal inflammation and underscore the potential of PD‐6 and GT‐8 as promising candidates for the prevention and improvement of UC‐related inflammatory diseases.

Source: Food Frontiers

DOI: 10.1002/fft2.469

Authors: Yaxi Zhou, Diandian Wang, Jinhong Guo, Yue Zheng, Hao Duan, Wenjie Yan

Institutions: Beijing Union University, Northwest A&F University

Language: English

Topic: Protein Hydrolysis and Bioactive Peptides

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,700