Figure 5 from Loss of STK11 Suppresses Lipid Metabolism and Attenuates KRAS-Induced Immunogenicity in Patients with Non–Small Cell Lung Cancer
Year: 2024
Type: other
Abstract: Mutant KRAS-induced immunogenicity requires the transcriptional upregulation of lipid metabolism. A, Tissue biopsies from treatment-naïve patients with NSCLC were subjected to whole-transcriptome RNA-seq as described and representative heat maps shown for select genes involved in lipid metabolism. B and C, Focused heatmaps are shown for select, significantly altered genes involved in lipid metabolic processes using a FDR-adjusted P value of <0.05. The percent CD8+ T-cell infiltration for patients arranged by combined KRAS mutation and (D) LPL mRNA expression, (E) LDLR mRNA expression, or (F) LDLRAD4 mRNA expression. Kaplan–Meier plots indicating months of OS for patients with NSCLC arranged by (G) CD8 mRNA expression, (H) KRAS mutation status alone, (I) combined KRAS and STK11 mutation statuses, (J) KRAS mutation status and LPL mRNA expression, (K) KRAS mutation status and LDLR mRNA expression, and (L) KRAS mutation status and LDLRAD4 mRNA expression. High, above median; low, below median; MT, mutated; NS, nonsignificant.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4402068440