Work

Preparation of a new reusable magnetic organocatalyst to synthesis of polyhydroquinoline derivatives as cytotoxic Agents: Synthesis and biological evaluation

Year: 2024

Type: article

Abstract: One of the most important ways to practice environmental stewardship is to turn waste materials into useful nanomaterials through ecological recycling. This work introduces a magnetic organocatalyst made from red mud waste, adding to the “greening” of global chemical processes. The new composite (Fe 3 O 4 @SiO 2 @(CH 2 ) 3 @4-(2-Aminoethyl)-morpholine) is introduced and characterized by different spectroscopic methods such as fourier transform infrared (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), mapping, thermogravimetric analysis (TGA) and vibrating-sample magnetometers (VSM). Catalytic activity of the catalyst was evaluated in production of some polyhydroquinoline derivatives and the results showed efficiency. Nine polyhydroquinoline derivatives were synthesized (M 1 -M 9 ) and their cytotoxic properties evaluated against two human-cancerous cell lines (Hep-G2 and SW480) by MTT assay . Most of the compounds exhibited high inhibitory activity against two studied cell lines. M 2 bearing 2-chloro substitution on phenyl ring was exhibited appropriate activity (IC 50 = 14.70 ± 3.11 µM) against SW480 cell line in comparison to cisplatin as positive control.

Source: Journal of Saudi Chemical Society

DOI: 10.1016/j.jscs.2024.101922

Authors: Leila Amiri-Zirtol, Ali Yargholi, Leila Emami, Zahra Karimi, Soghra Khabnadideh

Institutions: Shiraz University of Medical Sciences, Iran University of Science and Technology

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: hybrid

Estimated APC paid: $1,490