Work

Co(III)-Catalyzed Coupling of Enaminones with Oxadiazolones for Imidazole Synthesis

Year: 2024

Type: article

Abstract: Appendage speciation-oriented synthesis, as opposed to the conventional wisdom of skeleton speciation-oriented synthesis, is reported herein, emphasizing the maximization of type-, position-, and configuration-variance of appendages. A Co(III) catalytic protocol in accordance with this synthetic modality has been established for the coupling of enaminones and oxadiazolones to imidazoles, allowing the achievement of full position-variance of appendages. This translates to an expanded reaction and structural development scope and can provide fertile ground for productive organic synthesis.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c02736

Authors: Shuaixin Fan, Weiping Wu, Yachun Su, Xuanzhen Han, Zhixin Wang, Jin Zhu

Institution: Nanjing University

Language: English

Topic: Synthesis and Reactions of Organic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, Jiangsu Science and Technology Department

Awards: G117299061, G2814365926, G6916446599