Work

Synthesis and in vitro evaluation of cross-linked tragacanthin nanofibers as implants for delivery of cisplatin to hepatocellular carcinoma

Year: 2024

Type: article

Abstract: HNMR, powder X-ray diffraction analysis, and thermogravimetric analysis. They released the encapsulated drugs in a sustained manner at pH 7.4 over 4.5 days (∼275 h with ∼80 % release) following Higuchi (cisplatin) and Hixon-Crowell (caffeine) kinetics. In a cytotoxicity assay against HepG2 cell line the cisplatin-loaded nanofibers exhibited enhanced activity compared to that with the standard cisplatin and in the caspase activity assay it activated caspase 3 to a higher extent and 8 and 9 to double the extent (4-fold) of cisplatin, suggesting a higher apoptotic activity by the nanoformulation than the standard cisplatin. Thus, nanoformulation appeared to be a potential candidate for treating hepatocellular carcinoma as an implant.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e37304

Authors: Anam Shabbir, Mohammad Saeed Iqbal, Muhammad Zeeshan Saeed, Farooq Rashid

Institutions: Forman Christian College, COMSATS University Islamabad, Pakistan Institute of Nuclear Science and Technology

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100