Work

Synthesis and evaluation of lipoic acid – donepezil hybrids for Alzheimer’s disease using a straightforward strategy

Year: 2024

Type: article

Abstract: = 7.6 nM and 9.1 nM, respectively), selective against butyrylcholinesterase, and a notable neuroprotective effect, slightly better than that of lipoic acid, the present study suggests that O-desmethyldonepezil could serve as a platform for the straightforward design of donepezil hybrids.

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2024.129938

Authors: Vincent Luzet, Florentin Allemand, Chloé Richet, Barbara Dehecq, Alexandre Bonet, Dominique Harakat, Bernard Refouvelet, Hélène Martin, Bruno Cardey, Marc Pudlo

Institutions: Franche-Comté Électronique Mécanique Thermique et Optique - Sciences et Technologies, Université de Franche-Comté, Centre National de la Recherche Scientifique, Laboratoire Chrono-Environnement, Inserm, Interactions Hôte-Greffon-Tumeur & Ingénierie Cellulaire et Génique, Institut de Chimie Moléculaire de Reims, Université de Reims Champagne-Ardenne, Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,770

OpenAlex ID: W4402082801

FWCI: 1.194

Cites: 39

Cited by: 5

Related to: 10