Polyglandular Syndrome type III in a young patient: case report
Year: 2024
Type: article
Study design: Case Report
Abstract: Introduction: Autoimmune polyglandular syndromes (APS) are rare diseases defined by the coexistence of at least two autoimmune endocrine diseases. Objective: To describe a case of type III polyglandular syndrome in a young patient. Case report: Female, 37 years old, with hypothyroidism, presented with a weight loss of 9 kg, daily vomiting, asthenia, fatigue, and postprandial fullness for 3 months. He also reported arthritis in his wrists, shoulders, and hips. In laboratory tests, macrocytic and hyperchromic anemia associated with leukopenia, as well as hypovitaminosis B12, was observed. Pernicious anemia was investigated as the cause of this deficiency. Upper digestive endoscopy showed moderate gastritis – histopathological with gastric atrophy, positive anti-intrinsic factor antibody. Due to inflammatory arthralgia, ANA was requested, with an associated positive anti-dsDNA result of 1:80. In the EULAR/2019 diagnostic criteria for Systemic Lupus Erythematosus (SLE), she presented 14 points, thus she was diagnosed with SLE, and hydroxychloroquine (HXC) was started. Conclusion: SPA is rare, mainly in association with non-glandular autoimmunity, following an early diagnosis.
Source: Concilium
Authors: Talina Tassi Saraiva de Arruda, Gabrielle Christine Rocha Souza, Heloísa Antero Fernandes, Maria Luiza Vasconcelos Montenegro, Maria Juliana de Arruda Queiroga, Nicole Lira Melo Ferreira, Paulo Bernardo da Silveira Barros Filho, Rodrigo Rufino Pereira Silva, Thaíse Cristina Arcoverde Cardozo Da Silva, Thayna Almeida Batista
Institution: Universidade de Pernambuco
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4402087428