Perspectives of heart xenotransplantation: a quantitative analysis of this treatment in patients with heart disease
Year: 2024
Type: article
Study design: Systematic Review
Abstract: The shortage of human donors for heart transplants has driven research into viable alternatives, such as heart xenotransplantation. This study conducted a quantitative analysis of the perspectives of heart xenotransplantation in the treatment of patients with heart disease. The objective was to evaluate clinical efficacy, the immunosuppression techniques used, the results obtained in case studies and meta-analyses, and compare xenotransplantation with allogeneic transplantation methods. The methodology involved a literature review covering the period from 2014 to 2024, using databases such as Scielo, Google Scholar, scientific journals, repositories, and virtual libraries. Initially, 105 studies were found, of which 15 were selected after applying inclusion and exclusion criteria. The results showed that grafts from genetically modified pig hearts can survive for extended periods in non-human primates, with some survivals documented for up to 945 days. Effective immunosuppression techniques, such as CD40-CD154 costimulation blockade and the use of anti-CD20 antibodies, significantly reduced episodes of acute rejection. Practical implications include the potential reduction of waiting time for patients in need of transplants and offering new hope for those with terminal heart failure. However, technical, ethical, and biological challenges still need to be overcome. It is concluded that heart xenotransplantation is a promising field that deserves continuous attention and investment in research to advance towards safe and effective clinical application.
Source: Caderno Pedagógico
Authors: Ayla Almeida Aguiar, Eduardo Fernandes dos Santos, Felipe Otávio Saraiva França, Beatriz Martin Tuffy, Neomisia Brenna Galindo de Almeida, Larissa Emily Cardoso Dias, Isabelle Almeida Veloso, Maria Eduarda Prado Santos, Amanda Morais Ribeiro, Maria Augusta Monteiro Weffort, Eloá Lucif Mazurok, Matheus Castro da Silva, Sofia Maiolli Marques, José Vitor Uliano, Isabela Salonski Alves
Institution: Centro Universitário Cesumar
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402089066