Synergistic associations of CD33 variants and hypertension with brain and cognitive aging among dementia‐free older adults: A population‐based study
Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: CD33 rs3865444 and hypertension (HTN) are related to cognitive impairment, individually. However, little is known about their combined effects on cognitive function in older adults. METHODS: This population-based study included 4368 dementia-free participants (age ≥65 years) in the Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND-China), with data available in 1044 persons for gray matter volume and 85 persons for cerebral blood flow (CBF). We used general linear regression and mediation models to examine the associations of rs3865444 and HTN with cognition, brain atrophy, and CBF. RESULTS: Among rs3865444 CC carriers, HTN and late-life HTN were significantly associated with impaired cognition. Midlife and late-life HTN were correlated with brain atrophy. CD33 rs3865444 CC moderated the mediation effect of gray matter volume on the association between HTN and global cognition. HTN was correlated with low CBF in rs3865444 CC carriers. DISCUSSION: There are synergistic associations of CD33 rs3865444 and HTN with brain and cognitive aging in dementia-free older adults.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.14209
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Funders: Swedish Foundation for International Cooperation in Research and Higher Education, National Natural Science Foundation of China, Vetenskapsrådet, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Natural Science Foundation of Shandong Province, Shandong First Medical University, Postdoctoral Innovation Project of Shandong Province, National Institutes of Health, National Institute on Aging
Awards: G104586243, G1426253980, G2173848303, G2260548513, G2348741233, G2762113457, Exploring chronic hypoxia as a possible pathway linking clinical conditions of the heart, lungs, and blood with accelerated brain aging, Exploring the complex interplay between lifestyle factors, brain pathology, and cognitive reserve in cognitive decline and dementia, G3273638711, G3701712305, G433912421, G4443800563, G4607128697, FINGER-Pro: Evidence-based health promotion interventions for healthy aging: adapting and implementing the FINGER multidomain model across different settings and sociocultural contexts, Alzheimer's Disease Neuroimaging Initiative, G725152956, G8269203722
OpenAlex ID: W4402094949