Tandem Electrochemical Redox/Condensation Reaction Between 2‐Amino Nitrobenzenes and Aliphatic Alcohols: An Approach to Benzimidazoles
Year: 2024
Type: article
Abstract: Tandem reactions via electrocatalytic annulations have emerged as a strategy for the construction of heterocycles. Herein, a two‐component electrochemical annulation via sequential reduction, oxidation, and condensation steps to synthesize valuable benzimidazoles motifs is reported. This reaction, which utilizes electricity as both the oxidants and reductants, tolerates a broad range of functional groups. Detailed mechanistic studies including control experiments, cyclic voltammetry (CV) analysis, and key reaction intermediate characterization, reveals an intermolecular electrochemical redox/cyclization pathway.
Source: Advanced Synthesis & Catalysis
Authors: Zenghui Zhang, Wenjing Yang, Changji Liu, Xiao Yu, Shuyong Song, Chengcai Xia
Institutions: Shandong First Medical University, Shandong Tumor Hospital
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G3433195897
OpenAlex ID: W4402096822