Year: 2024
Type: article
Abstract: Herein, we have designed and synthesised a 2,6‐dihydroxybenzoyl‐hydrazone (compound 3) fluorophore through a concise strategy. Molecular dynamics and quantum mechanical simulations revealed that long range charge transfer (CT) to be the underlying mechanism for the emissive property of compound 3. Confocal microscopy and cell viability assays confirmed that within 3 h, compound 3 homed into the Golgi‐apparatus of colon cancer cells (HCT‐116) selectively compared to the breast (MCF7), lung (A549), cervical (HeLa) cancer cells and non‐cancerous retinal epithelial pigment cells (RPE‐1) with negligible toxicity. This novel fluorophore has potential to image Golgi‐apparatus in a cancer cell specific manner for diagnosis.
Source: ChemBioChem
Institution: Indian Institute of Technology Gandhinagar
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4402096834