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Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment

Year: 2024
Type: article
Abstract: As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial. Here, we generated induced pluripotent stem cells (iPSCs) from Peripheral Blood Mononuclear Cells (PBMCs) retrieved from four ADHD patients (two MPH responders and two non-responders) using Sendai virus. These lines might be helpful for the in vitro investigation of ADHD pathophysiology in a patient-specific manner.
DOI: 10.1016/j.scr.2024.103546
Authors: Cristine Marie Yde Ohki, Natalie Monet Walter, Michelle Rickli, Cedric Iseli, Anna Maria Werling, Christian Döring, Belén Rubio, Per Hoffmann, Stefan Herms, Susanne Walitza, Edna Grünblatt
Institutions: University of Zurich, Psychiatrische Universitätsklinik Zürich, University of Bonn, University of Basel, University Hospital Bonn, ETH Zurich
Language: English
Open Access status: gold
Estimated APC paid: $2,320
OpenAlex ID: W4402115564
FWCI: 0.471
Cites: 4
Cited by: 4
Related to: 10