Combined analysis of gut microbiota and metabolomics in high-fat model mice fed with Chlorella pyrenoidosa peptides
Year: 2024
Type: article
Abstract: Chlorella pyrenoidosa peptides (SISISVAGGGR, T1) can effectively alleviate obesity and related metabolic disorders in high-fat mice. However, their lipid-lowering mechanism is still unclear. This research endeavor sought to delve into the potential mediators of T1 anti-obesity in high-fat mice through macrogenomics analyses combined with untargeted metabolomics analyses. The results showed that T1 alleviated HFD-induced increases in body weight, epididymal fat weight, TG, LDL, AST, TNF-α, and IL-1β levels, and increased HDL level. Moreover, T1 reversed the HFD-induced gut microbiota dysbiosis. Specifically, T1 resulted in a massive proliferation of Bacteroides , Parabacteroides , and Alistipes , as well as increased levels of metabolites such as DL-arginine, N-stearoyl GABA, and decreased levels of 7α,24(S)-dihydroxy-4-cholesten-3-one, and hexadecanedioic acid. Correlation analysis showed that T1 alleviated HFD-induced obesity metabolic syndrome and associated inflammation by modulating specific gut microbiota and related metabolites. This provides new ideas for the treatment of diet-induced obesity and related metabolic disorders.
Source: Journal of Functional Foods
Authors: Wenxiang Liu, Jiaying Wang, Qi Gao, Wenjuan Shen, Peifang Weng, Zufang Wu, Wenyan Qin, Yanan Liu
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W4402117608