Work

Strain and hyaluronic acid interact to regulate ovarian cancer cell proliferation, migration, and drug resistance

Year: 2024

Type: article

Abstract: model, we were able to identify how interactions of strain and HA as in the TME synergistically drive enhanced proliferation and migration in an ovarian tumor model line, while decreasing response to paclitaxel treatment. This study demonstrates the importance of elucidating how the mechanical forces present in the ovarian TME drive disease progression and response to treatment.

Source: Mechanobiology in Medicine

DOI: 10.1016/j.mbm.2024.100094

Authors: Maranda Kramer, Allyson Criswell, Kamari Marzette, Emerson Cutcliffe, Mary Kathryn Sewell-Loftin

Institutions: University of Alabama at Birmingham, O'Neal Comprehensive Cancer Center

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,600