Work

Intrinsic ADRB2 inhibition improves CAR-T cell therapy efficacy against prostate cancer

Year: 2024

Type: article

Abstract: -CAR-T cells performed better than conventional CAR-T cells in eradicating prostate tumors. The study provides the basis for future clinical and translational CAR-T cell research to focus on adrenergic stress-mediated challenges in the tumor microenvironment of stressed tumors.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2024.08.028

Authors: Iqra Ajmal, Muhammad Asad Farooq, Yixin Duan, Jie Yao, Yaoxin Gao, Xinhui Hui, Yujia Ge, Yiran Chen, Yaojun Ren, Bingtan Du, Wenzheng Jiang

Institutions: East China Normal University, Zhengzhou University, First Affiliated Hospital of Zhengzhou University, Xinjiang Normal University

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,900

Funders: National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality, East China Normal University, National Key Research and Development Program of China

Awards: G381500128, G5285045448, G5676071834, G7915136340

OpenAlex ID: W4402126913

FWCI: 5.485

Cites: 57

Cited by: 37

Related to: 10