Work

Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children

Year: 2024

Type: article

Abstract: Although surfactant protein (SP) genetic variants are associated with respiratory syncytial virus (RSV) severity, the impact of single-nucleotide polymorphism (SNP)-SNP interactions of SP genes remained unexplored. Using advanced statistical models, we uncovered 22 SNP-SNP interactions associated with RSV severity, with notable involvement of SFTPA1 and SFTPA2 SNPs. This highlights the comprehensive role of all SPs in genetic susceptibility to RSV severity, shedding light on potential avenues for targeted interventions.

Source: Physiological Genomics

DOI: 10.1152/physiolgenomics.00045.2024