Work

Transdermal Scopolamine for Treatment-Resistant Major Depressive Disorder

Year: 2024

Type: article

Abstract: Conventional antidepressants are useful in the treatment of major depressive disorder (MDD) but are limited by their delayed onset of action and lack of adequate therapeutic response in approximately one-third of patients. This has led to a quest for faster-acting and more effective antidepressants. Scopolamine exhibits rapid antidepressant effects when administered intravenously. We report a case of a female with treatment-resistant depression (TRD) who responded to transdermal scopolamine. She had a rapid (within three days) and sustained (119 days) response to transdermal scopolamine. Further research into the use of transdermal scopolamine for the treatment of depression is recommended.

Source: Cureus

DOI: 10.7759/cureus.68447

Authors: Mitchell B Liester, Delia S Shash

Institutions: University of Arizona, University of Colorado Anschutz, University of Colorado Colorado Springs

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402132244