Work

Daily physical activity and prognostic implications in patients with heart failure: an accelerometer study

Year: 2024

Type: article

Abstract: Background Physical activity (PA) measured by accelerometry is proposed as a novel trial endpoint for heart failure (HF). However, standardised methods and associations with established markers are lacking. This study aimed to examine PA measurements and accelerometer repeatability in patients with HF and age- and sex-matched controls, and study correlations with established prognostic HF markers, body composition, and quality of life (QoL). Methods Accelerometry was performed in 105 patients with HF with left ventricular ejection fraction (LVEF) ≤ 40% and in 46 controls. Participants also underwent dual X-ray absorptiometry, cardiopulmonary exercise testing, a six-minute walking test (6MWT), echocardiography, and NT-proBNP measurement, and completed a QoL questionnaire. Results Average acceleration was markedly reduced in patients with HF compared with healthy controls (16.1 ± 4.8 mg vs 27.2 ± 8.5 mg, p < 0.001). Healthy controls spent a median daily 56 min (IQR 41–96 min) in moderate-to-vigorous PA (MVPA), whereas HF patients spent only 12 min (IQR 6–24) in MVPA. In HF patients, average acceleration correlated moderately with 6MWT ( R = 0.41, p < 0.001) and maximal oxygen uptake (peak V O 2 ) ( R = 0.36, p < 0.001) but not with NT-proBNP, LVEF, or QoL. Patients in NYHA class II showed a higher average acceleration than patients in NYHA III (16.6 ± 4.9 mg vs 14.0 ± 3.6 mg, p = 0.01). Conclusions Daily PA was severely reduced in patients with HF compared with healthy controls. In HF patients, we found moderate correlations of accelerometer measurements with markers of physical capacity but not with LVEF or NT-proBNP. Trial registration NCT05063955. Registered 01 June 2021—retrospectively registered. Graphical abstract

Source: Clinical Research in Cardiology

DOI: 10.1007/s00392-024-02508-0

Authors: Andreas Bugge Tinggaard, Lotte Sørensen, Kristian Vissing, Niels Jessen, Helene Nørrelund, Henrik Wiggers

Institutions: Aarhus University, Aarhus University Hospital, Steno Diabetes Center Aarhus

Language: English

Topic: Heart Failure Treatment and Management

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,190