Hsa_circ_ROBO1 competes with miR-324-3p and upregulates NME1 to promote tumor metastasis in nasopharyngeal carcinoma
Year: 2024
Type: article
Abstract: BACKGROUND: This work aims to explore circ_ROBO1's function in nasopharyngeal carcinoma (NPC). METHODS: circ_ROBO1 expression in NPC tissues and cell lines was measured. The regulation of circ_ROBO1 and/or miR-324-3p on the proliferation, migration, invasion, and apoptosis of NPC cells was investigated by functional experiments. The interplay between circ_ROBO1, miR-324-3p, and NME1 was explored. Tumor growth and metastasis were studied in mice. RESULTS: circ_ROBO1 was overexpressed in NPC. Knockdown of circ_ROBO1 repressed proliferation, migration, and invasion and induced apoptosis of NPC cells. Loss of circ_ROBO1 reduced tumor growth and metastasis in mice. circ_ROBO1 competed with miR-324-3p to upregulate NME1. Lowering miR-324-3p expression impaired the effect of knockdown of circ_ROBO1on NPC cells. CONCLUSION: Overexpressed circ_ROBO1 promotes NPC development by modifying the miR-324-3p/NME1 axis.
Source: Discover Oncology
Authors: FenFeng Liang, Hai Zhao, GengChun Liu, MeiLing Huang, ZhengJia Peng
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,590
OpenAlex ID: W4402134756