Hypercalcemia in Hodgkin’s Lymphoma – A Case Report
Year: 2024
Type: article
Study design: Case Report
Abstract: Hypercalcemia, though rare is an important cause of diffuse aches and pains. More relevant is the cause, which can sometimes be treatable and at other times not. Here, we present a case of 48-year-old man with lymphadenopathy, hypercalcemia and acute kidney injury who was diagnosed with Hodgkin’s lymphoma. This case is about a 48-year-old man who presented with symptoms of hypercalcemia and generalised lymphadenopathy. With a predisposition of EBV infection, Hodgkin’s lymphoma was identified to be the source of hypercalcemia, leading on to the hypercalcemic nephropathy. Hypercalcemia is usually seen with non-hodgkins lymphoma and only a few reports of hypercalcemia associated with Hodgkins lymphoma had been published. The usual mechanism is Vit D dependent, however, in our patient hypercalcemia was probably mediated by PTHrP; since both the vit D and activated vit D levels were normal. The presence of PTHrP mediated hypercalcemia Hodgkin’s lymphoma makes our case rare, as an uncommon presentation of a disease with yet another uncommon mechanism underlying.
Authors: Nikitha Kunnath, Vinod Vallomparbath Sathiaseelan, Amrutha Prabhakaran, Anjana Attupurath Mana
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402137276