Work

Heterocycle-guided synthesis of m -hetarylanilines via three-component benzannulation

Year: 2024

Type: article

Abstract: A one-pot three-component synthesis of substituted meta -hetarylanilines from heterocycle-substituted 1,3-diketones has been developed. The electron-withdrawing power of the heterocyclic substituent (which can be estimated on the basis of calculated Hammett constants) in the 1,3-diketone plays a pivotal role in the studied reaction. The series of meta -hetarylanilines prepared (21–85% isolated yield) demonstrates the synthetic utility of the developed method.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.20.188

Authors: Andrey R Galeev, Maksim V Dmitriev, Alexander S Novikov, Andrey N Maslivets

Institutions: Perm State University, Peoples' Friendship University of Russia, St Petersburg University

Language: English

Topic: Cyclization and Aryne Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Ministry of Science and Higher Education of the Russian Federation, RUDN University

Awards: G5636627374, G6899764260, G7913798890