Work

HBr/TMSO/HFIP Mediated Chemoselective Modifications of Pyrrolo[2,1‐a]Isoquinolines

Year: 2024

Type: article

Abstract: The combination of HBr, TMSO (tetramethylene sulfoxide) and HFIP (hexafluoroisopropanol) has been utilized in the modification of pyrrolo[2,1‐a]isoquinoline derivatives through bromination, dimerization and sulfenylation respectively. In these processes, HBr serves as the source of bromine and TMSO acts as an oxidant. HFIP also plays an essential role for the oxidative dimerization. Chemoselectivity can be easily controlled by adjusting the parameters such as reaction time, ratio of reagents and the addition of nucleophile.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202400323

Authors: Yun‐Meng Li, Man Jiang, Jing Zhou, Hai‐Lei Cui

Institution: Chongqing University of Arts and Sciences

Language: English

Topic: Synthesis and Reactivity of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Chongqing University, Chongqing Municipal Education Commission, Chongqing University of Science and Technology

Awards: 亲核性亚胺衍生的1，n-偶极体环化反应研究, G3714752632