Cytokine and chemokine profiling in chronic hepatitis- C and -B virus infections with high viral load
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Primary defects in innate immunity in chronic hepatitis-C and -B may shift towards dysregulated adaptive immunity.Cytokines are critical immune regulators.Aim: To clarify cytokines and chemokines in chronic hepatitis-C and -B to investigate the innate and adaptive immunity.Methods: Twenty-seven serum cytokines were evaluated in 27 patients with chronic hepatitis-C (genotype 1 [n=20], genotype 2 [n=7], hepatitis-C virus.RNA 5.72 ± 3.17 Log IU/ mL),12 patients with chronic hepatitis-B (e-antigen [+] [n=5], e-Ag [-] [n=7], genotype B [n=2], genotype C [n=9], hepatitis-B virus.DNA 6.19 ± 1.31 Log-copies/mL) and controls (n=5).Results: Th1 and Th2 cytokines levels were significantly higher (p< 0.05) in chronic hepatitis-B than those in chronic hepatitis-C.Interleukin-12 and -15 levels were significantly higher (p < 0.05) in chronic hepatitis-B than those in chronic hepatitis C. CXCL8 and -10 were significantly higher (p < 0.05) in chronic hepatitis-C and -B than those in controls.Immune responses were stronger in patients with chronic hepatitis-C (genotype 2) than in those with chronic hepatitis-C (genotype1).The results showed a distinct state of immunity among chronic hepatitis-B and -C.Conclusions: Skewing immunity was observed in chronic hepatitis-B and -C as well as impairments to induce innate immunity linked to adaptive immunity.Augmenting immunological strategies are necessary for the treatment and management of chronic hepatitis-B and -C with a high viral load.
Source: Journal of Immunology
Author: Internal Medicine
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4402152426