15 % Azelaic acid gel modify the skin microbiota of acne vulgaris
Year: 2024
Type: article
Study design: Clinical Trial
Abstract: Background: Over 85 % of teenagers and young adults worldwide suffer from acne vulgaris (AV), a widespread chronic condition that makes up 15–20 % of all skin disease cases. Objective: For AV treatment, 15 % Azelaic acid gel has long been promoted as a safe and efficient therapeutic agent. Our goal was to investigate how the skin microbiota of individuals with acne vulgaris was affected by a 15 % Azelaic acid gel. Materials and methods: A total of 55 volunteers who clearly displayed signs of acne vulgaris were recruited. They used a 15 % Azelaic acid gel every day for 28 days, with 3 follow-up appointments on the 1st, 14th, and 28th days. The V3–V4 region of the 16S rRNA gene was sequenced to examine the skin microbial samples that were collected. Results: The taxonomic makeup of the microbiome communities in acne-affected vs. acne-free locations differs significantly. The Alpha and Beta diversity of acne-affected areas improved after 28 days of applying 15 % Azelaic acid gel. There were slight decreases in values of Cutibacterium and Staphylococci, which were not statistically significant. Lactobacillus increased considerably (p* = 0.01) from 0.97 % to 1.60 %. Propionibacterium and Staphylococci relative numbers after extended usage of 15 % Azelaic acid gel were similar to those of skin not affected by acne. Conclusion: 15 % Azelaic acid gel aided in modifying the skin microbiota within the acne vulgaris group increased the diversity of skin microbiota in the acne-affected area.
Authors: Wenxin Yu, Huchi Shen, Beilei Cai, Yuanruo Xie, Yue Wang, Jing Wang
Institution: Jiangnan University
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4402162864