Work

Synthesis of Diethyl 6-Amino-1-aryl-2-oxo-1,2-dihydropyridine-3,5-carboxylate

Year: 2024

Type: article

Abstract: It was found that the reaction of malonic acid N-arylamidoesters with ethyl 2-cyano-3-ethoxyacrylate in ethanol in the presence of equimolar amounts of triethylamine both at room temperature and under reflux leads to the formation of previously unknown diethyl 6-amino-1-aryl-2-oxo-1,2-dihydropyridine-3,5-carboxylates with yields of 40–70%. Structure of the obtained compounds was confirmed by NMR and IR spectroscopy data. Antibacterial activity of some of the obtained compounds was studied.

Source: Журнал Общей Химии

DOI: 10.31857/s0044460x24040011

Authors: A. Kh. Khachatryan, K. A. Avagyan, A. E. Badasyan

Institutions: A. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia

Language: English

Topic: Synthesis of heterocyclic compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4402167394

FWCI:

Cites: 23

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Related to: 10