Work

Comparative Analysis of Comprehensive Genomic Profile in Thymomas and Recurrent Thymomas Reveals Potentially Actionable Mutations for Target Therapies

Year: 2024

Type: article

Study design: Observational Study

Abstract: CGP do not substantially differ between initial tumor vs tumor recurrence and recurrent thymomas vs non-recurrent thymomas. Cell-cycle control genes alterations are associated with an early recurrence after thymectomy. Multiple target therapies are potentially available by performing a comprehensive CGP, suggesting that a precision medicine approach on these patients could be further explored.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms25179560

Authors: Filippo Lococo, Elisa De Paolis, Jessica Evangelista, Andrea Dell’Amore, Diana Giannarelli, Marco Chiappetta, Annalisa Campanella, Carolina Sassorossi, Alessandra Cancellieri, Fiorella Calabrese, Alessandra Conca, Emanuele Vita, Angelo Minucci, Emilio Bria, Angelo Castello, Andrea Urbani, Federico Rea, Stefano Margaritora, Giovanni Scambia

Institutions: Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic, University of Padua, Istituti di Ricovero e Cura a Carattere Scientifico, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Language: English

Topic: Myasthenia Gravis and Thymoma

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,296

Funder: Università degli Studi di Padova

OpenAlex ID: W4402167851

FWCI: 0.465

Cites: 50

Cited by: 2

Related to: 10