Work

Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease

Year: 2025

Type: review

Abstract: We examine the relationship between sleep, glymphatics and Alzheimer’s disease (AD), and recent work questioning glymphatic clearance during sleep. We highlight a need for understanding glymphatic and/or other mechanism of clearance during sleep, and review glymphatic flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances and enhance clearance. Further research could elucidate a linkage between DORAs, improved sleep and reducing AD pathophysiology.

Source: npj Biological Timing and Sleep

DOI: 10.1038/s44323-025-00025-5

Authors: S. M. Ragsdale, J. M. Radovich, I. I. Coiduras, W. V. McCall, S. C. Grant, C. Lee, A. Wilber

Institutions: Florida State University, Florida A&M University - Florida State University College of Engineering, National High Magnetic Field Laboratory, Augusta University

Language: English

Topic: Sleep and Wakefulness Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590

Funders: National Science Foundation, Florida Department of Health, National High Magnetic Field Laboratory, National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, Division of Materials Research, High Magnetic Field Laboratory, Chinese Academy of Sciences

Awards: G1019936685, A novel cell-based platform to study human circadian disorders, G2169024908, Molecular mechanisms underlying human circadian sleep disorders, MR Analysis of Pre-Conditioned Human Mesenchymal Stem Cells for Stroke Therapy, G5183596123, G5435935363, Parietal-hippocampal network in the triple transgenic mouse model of Alzheimers, Parietal-hippocampal network in the triple transgenic mouse model of Alzheimers, Dysfunction of Sodium Homeostasis in Migraine, G6777198254, G7063027373, National High Magnetic Field Laboratory Renewal 2023-2027, G738160294, G742574937, G8152425740, G8466211961, Neurobiological Basis of Reference Frame Coordination for Spatial Memory to Action Transformations, Cortical-hippocampal brain dynamics during sleep following spatial learning in rodents modeling Tau and AB aggregation feature of Alzheimer's disease

OpenAlex ID: W4408243174

FWCI: 2.876

Cites: 152

Cited by: 26

Related to: 10