Work

Case report: Germline BRCA 2 mutation in primary peritoneal carcinoma: a rare malignancy

Year: 2024

Type: article

Abstract: Background: Primary peritoneal carcinoma (PPC) is a rare malignancy. Clinically, its histological morphology resembles that of epithelial ovarian tumors (EOC), often leading to misdiagnosis. Diagnosis and treatment of PPC are time-sensitive because of the rapidly progressive nature of the disease. Case report: Herein, we report the case of a 54-year-old woman who was initially diagnosed with ovarian cancer; however, extensive workup showed evidence of Müllerian PPC origin. Furthermore, the patient harbored a targetable BRCA mutation. Conclusion: The patient was treated with the BRCA-targeting agents and had a good prognosis after surgery.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2024.1428918

Authors: Yan-Ying Huang, Yue Zhang, Wen-Jun Xie, Zhao-Dong Li

Institution: Hangzhou Red Cross Hospital

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295