Work

Risk of multiple primary cancers in patients with atypical fibroxanthoma/pleomorphic dermal sarcoma: A SEER analysis

Year: 2024

Type: article

Abstract: To the Editor: Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are malignant mesenchymal dermal neoplasms considered to be on a spectrum of disease severity.1 While both AFX and PDS are locally aggressive, AFX rarely metastasizes, while PDS is associated with a high risk of recurrence and metastasis.1,2 AFX/PDS classically presents in elderly patients on sun-exposed or previously radiated surfaces as a solitary, red nodule or papule.3,4 AFX has a 5-year recurrence rate around 7%,2 and the risk of transformation from AFX to PDS after local AFX recurrence is 13%.

Source: JAAD International

DOI: 10.1016/j.jdin.2024.08.003

Authors: Vraj K. Shah, Rajiv I. Nijhawan

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Nonmelanoma Skin Cancer Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,575