HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis
Year: 2024
Type: article
Abstract: lncRNA can regulate tumorigenesis development and distant metastasis of colorectal cancer (CRC). However, the detailed molecular mechanisms are still largely unknown. Using RNA-sequencing data, RT-qPCR, and FISH assay, we found that HIF1A-AS2 was upregulated in CRC tissues and associated with poor prognosis. Functional experiments were performed to determine the roles of HIF1A-AS2 in tumor progression and we found that HIF1A-AS2 can promote the proliferation, metastasis, and aerobic glycolysis of CRC cells. Mechanistically, HIF1A-AS2 can promote FOXC1 expression by sponging miR-141-3p. SP1 can transcriptionally activate HIF1A-AS2. Further, HIF1A-AS2 can be packaged into exosomes and promote the malignant phenotype of recipient tumor cells. Taken together, we discovered that SP1-induced HIF1A-AS2 can promote the metabolic reprogramming and progression of CRC via miR-141-3p/FOXC1 axis. HIF1A-AS2 is a promising diagnostic marker and treatment target in CRC.
Source: Cell Death and Disease
Authors: Xinyang Zhong, Yaxian Wang, Yaxian Wang, Xuefeng He, Xinxin He, Zijuan Hu, Huixia Huang, Jiayu Chen, Keji Chen, Ping Wei, Senlin Zhao, Yilin Wang, Yilin Wang, Hong Zhang, Bo Feng, Dawei Li
Institutions: Shanghai Medical College of Fudan University, Fudan University, Fudan University Shanghai Cancer Center, Second Affiliated Hospital of Zhejiang University, Zhejiang University, Guangxi Medical University, Tumor Hospital of Guangxi Medical University, Sheng Jing Hospital, China Medical University, Shanghai Jiao Tong University, Ruijin Hospital
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,790
Awards: G3425242362, G8381024953
OpenAlex ID: W4402182570