Work

Implementing non-invasive prenatal testing in a national screening program: Lessons learned from the TRIDENT studies

Year: 2024

Type: article

Abstract: The Dutch NIPT Consortium, a multidisciplinary collaboration of stakeholders in prenatal care initiated and launched the TRIDENT studies. The goal of the TRIDENT studies was to implement non-invasive prenatal testing (NIPT), first as a contingent (second-tier) and later as a first-tier test, and to evaluate this implementation. This paper describes how NIPT can be successfully implemented in a country or state. Important factors include the significance of forming a consortium and encouraging cooperation among relevant stakeholders, appropriate training for obstetric care professionals, and taking into account the perspectives of pregnant women when implementing prenatal tests. We describe the advantages of high sensitivity and specificity when comparing contingent NIPT with first-tier NIPT. This paper emphasizes the value of pre- and post-test counselling and the requirement for a standardized method of information delivery and value clarification, to assist couples in decision making for prenatal screening.

Source: Best Practice & Research Clinical Obstetrics & Gynaecology

DOI: 10.1016/j.bpobgyn.2024.102543

Authors: Matea Skojo, Malgorzata I. Srebniak, Lidewij Henneman, Erik A. Sistermans, Karuna R.M. van der Meij

Institutions: Erasmus MC, Erasmus University Rotterdam, Amsterdam University Medical Centers, Amsterdam Reproduction Development, Vrije Universiteit Amsterdam

Language: English

Topic: Prenatal Screening and Diagnostics

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,160