Supramolecular hydrogel of mycophenolic acid for treating allergic conjunctivitis
Year: 2024
Type: article
Abstract: Mycophenolic acid (MPA) is an immunosuppressant less commonly utilized in allergic conjunctivitis. Peptide-based hydrogels improve material performance and are used in different biomedical applications. The current study reported that a cationic peptide Nap-FFKK and MPA were co-assembled into K–M hydrogel for sustained MPA delivery. The study evaluated cytotoxicity in vitro and its effectiveness in alleviating allergic conjunctivitis symptoms with a model. The current study demonstrates a promising strategy for using peptides as vehicles for sustained MPA delivery to the eye for ophthalmic applications.
Authors: Guojuan Pu, Zhen Liang, Jieran Shi, Ping Lu, Huiyun Xia, Yuan Tao, Huiling Qing, Junjie Zhang
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,400
OpenAlex ID: W4402188348