Immunotherapy and transarterial embolization in patients with metastatic melanoma: a retrospective cohort study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Aim: To investigate how the sequence of checkpoint immunotherapy (CPI) and transarterial embolization (TAE) affects overall survival (OS) of patients with metastatic melanoma.Materials & methods: This retrospective cohort study included 65 patients with metastatic melanoma who underwent both TAE and CPI between September 2011 and January 2022.Results: Significantly higher OS was seen in patients who received CPI before and after embolization (22 months, 95% CI 14-NR, p < 0.001) compared with only before embolization (4.5 months 95% CI, 14-NR). ≤3 hepatic metastasis (p < 0.01), more TAE procedures (p < 0.001) and CPI sequence (before and after embolization) (p < 0.001) were independent predictors of survival.Conclusion: Metastatic melanoma patients who underwent TAE have longer survival when CPI was sequenced both before and after embolization.
Source: Immunotherapy
Authors: Leila Haghani, Chenyang Zhan, Hooman Yarmohammadi, Etay Ziv, Vlasios S Sotirchos, Debkumar Sarkar, Alexander N Shoushtari, Joseph P Erinjeri
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: Cancer Center Support Grant
OpenAlex ID: W4402192240