Significance of AST to ALT Ratio in Predicting Esophageal Varices in Cirrhotic Patients taking Esophagogastroduodenoscopy as Gold Standard
Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective: To determine the significance of AST to ALT ratio in predicting esophageal varices taking esophagogastroduodenoscopy (EGD) as the gold standard in cirrhotic patients Methods: This six-month cross-sectional study included 193 patients. It was conducted in medical ward of DHQ Teaching Hospital, Gujrat from 11th Jul, 2021 to 11th Jan, 2022. Proper history, examination and ultrasound abdomen was done of every patient to make the diagnosis cirrhosis. LFTs and EGD was done of every patient and all data was saved. AST/ALT was calculated and endoscopic presence or absence of esophageal varices was recorded. SPSS 23was used to enter and analyze the data. Results: Mean age (years) was 55.68+13.69, eighty-seven (45.1%) were male and 106 (54.9%) females. There were 74 (38.3%) patients of esophageal varices who had AST/ALT ratio more than > 1.12 and 119 (61.7%) patients with less than 1.12 value. On endoscopy 89 (46.1%) patients had esophageal varices. A 2 by 2 table was utilized to determine the diagnostic accuracy, sensitivity, specificity, PPV (positive predictive value) and NPV (negative predictive value) of AST to ALT ratio in predicting esophageal varices taking EGD as gold standard which was 65.28%, 54.02%, 74.53%, 63.51% and 66.39% respectively. Conclusion: An effective non-invasive diagnostic tool for predicting esophageal varices in cirrhotic patients is the AST/ALT ratio
Authors: Syed Zeeshan Ilyas, Faisal Rasheed, Irfan Younus, Muhammad Afzal Choudhry, Furqan Tahir, Adnan Qadir
Institutions: Abbasi Shaheed Hospital, Rawalpindi Medical University
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4402192347