Insulin-like growth factor-2 mRNA-binding protein 2 facilitates post-ischemic angiogenesis by increasing the stability of fibroblast growth factor 2 mRNA and its protein expression
Year: 2024
Type: article
Abstract: Background: Post-ischemic angiogenesis is crucial for reestablishing blood flow in conditions such as peripheral artery disease (PAD). The role of insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP2) in post-transcriptional RNA metabolism and its involvement in post-ischemic angiogenesis remains unclear. Methods: mRNA, as well as its impact on FGF2 protein expression. Results: mRNA to increase its stability. This interaction resulted in increased levels of FGF2 protein and secretion, ultimately promoting angiogenesis. Conclusions: mRNA stability and FGF2 protein expression and secretion. These findings underscore IGF2BP2's therapeutic potential in ischemic conditions, such as PAD.
Source: Heliyon
Authors: Shuai Ma, Yiqing Hu, Wangguo Xu, Weidong Xiong, Xinyu Xu, Yajie Hou, Ying Wang, Panke Chen, Wenbi Yang, Hao Lu, Yongchao Zhao
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,100
Awards: G1059295449, G1464416228, G8662048660
OpenAlex ID: W4402198710