Work

Muscle protein catabolism and splanchnic arginine consumption drive arginine dysregulation during Pseudomonas aeruginosa-induced early acute sepsis in swine

Year: 2024

Type: article

Abstract: arginine synthesis, citrulline production, and transorgan PDV release of citrulline, glutamine and arginine did not differ between sepsis and controls. However, Wb (p<0.0001) and muscle (p<0.001) protein breakdown were increased, suggesting that the enhanced arginine production is predominantly derived from muscle breakdown in sepsis. In conclusion, live-bacterium sepsis increases muscle arginine release and liver uptake, mirroring previous pig endotoxemia studies. In contrast to observations in humans, acute live-bacterium sepsis in pigs does not change citrulline production or arterial arginine concentration. We therefore conclude that the arginine dysregulation observed in human sepsis is possibly initiated by enhanced protein catabolism and splanchnic arginine catabolism, while decreased arterial arginine concentration and citrulline metabolism may require more time to fully manifest in patients.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00257.2023

Authors: Sarah A. Rice, Gabriella A. M. Ten Have, Marielle P. K. J. Engelen, Nicolaas E. P. Deutz

Institutions: University of Alaska Fairbanks, Texas A&M University

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources