Figure S7 from Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor
Year: 2024
Type: other
Abstract: Supplemental Figure 7: Macrophage subtypes are unaffected by treatment in patients in SR-1. (A) Baseline and on-treatment biopsies from patients (n = 6 paired samples) in the SR-1 trial were analyzed by multiplex immunofluorescence using the indicated antibodies. Representative image of the macrophage panel is shown. (B) Densities of total macrophages (CD68+ or CD163+ cells). (C) Densities of M1 polarized macrophages (CD86+IRF5+). (D) Densities of M2 polarized macrophages (CD206+CD163+).
Authors: Paul E. Oberstein, Andressa Dias Costa, Emily A. Kawaler, Victoire Cardot-Ruffino, Osama E. Rahma, Nina Beri, Harshabad Singh, Thomas A. Abrams, Leah H. Biller, James M. Cleary, Peter Enzinger, Brandon M. Huffman, Nadine J. McCleary, Kimberly J. Perez, Douglas A. Rubinson, Benjamin L. Schlechter, Rishi Surana, Matthew B. Yurgelun, S. Jennifer Wang, Joshua Remland, Lauren K. Brais, Naima Bollenrucher, Eugena Chang, Lestat R. Ali, Patrick J. Lenehan, Igor Dolgalev, Gregor Werba, Cibelle Lima, C. Elizabeth Keheler, Keri M. Sullivan, Michael Dougan, Cristina Hajdu, Maya Dajee, Marc R. Pelletier, Saloney Nazeer, Matthew Squires, Dafna Bar-Sagi, Brian M. Wolpin, Jonathan A. Nowak, Diane M. Simeone, Stephanie K. Dougan
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4402201052