Work

Lipid emulsion attenuates vasodilation by decreasing intracellular calcium and nitric oxide in vascular endothelial cells

Year: 2024

Type: article

Abstract: ) elevation in endothelial cells following cyclopiazonic acid (CPA) treatment, suggesting enhanced endoplasmic reticulum (ER) calcium reuptake. Additionally, nitric oxide (NO) fluorescence assays showed a decrease in NO production upon ATP stimulation post-LE pretreatment of endothelial cells. Taken together, these results indicate that the reversal of vasodilation by LE may involve enhanced ER calcium uptake, leading to a reduction in intracellular calcium concentration and suppression of NO (key vasodilatory agent) synthesis.

Source: Heliyon

DOI: 10.1016/j.heliyon.2024.e37353

Authors: Ling Chen, Hui Bai, Jing Zhao, Panpan Zhang, Xinhua Zhang, Dezhi Kong, Changzheng Dong, Wei Zhang

Institutions: Hebei Medical University, Fourth Hospital of Hebei Medical University, Second Hospital of Hebei Medical University, Hebei General Hospital

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100

Funders: National Science Foundation, Health Commission of Hebei Province, National Natural Science Foundation of China, Natural Science Foundation of Hebei Province, Hebei Medical University, National Key Research and Development Program of China, National Key Research and Development Program of China Stem Cell and Translational Research

Awards: G1032635764, G1770200266, G6139151035, G7314406429, G7831653944, G944439070

OpenAlex ID: W4402203217

FWCI: 0.239

Cites: 34

Cited by: 1

Related to: 10