Work

Concise Synthesis of Azaphenanthrene Alkaloid Eupolauramine Via Au(I)‐Catalyzed Cycloisomerization and Intramolecular Ullmann‐Type Coupling Reaction

Year: 2024

Type: article

Abstract: ABSTRACT A concise and efficient synthesis of the γ‐lactam‐fused azaphenanthrene alkaloid eupolauramine has been achieved. The key feature of the synthesis involves Au(I)‐catalyzed cycloisomerization of N‐naphthyl aminobutynamide intermediate and subsequent intramolecular Ullmann‐type coupling reaction. This study clearly demonstrated the usefulness of coinage metal‐catalyzed cycloisomerization strategy in the construction of architecturally sophisticated pyridine‐fused heterocyclic scaffolds.

Source: Journal of Heterocyclic Chemistry

DOI: 10.1002/jhet.4889

Authors: Eunyeong Kim, Young Taek Han

Institution: Dankook University

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Research Foundation, Dankook University, National Research Foundation of Korea, Ministry of Science and ICT, South Korea

Award: G8183806163