Work

Epigenetics of nonobstructive azoospermia

Year: 2024

Type: review

Abstract: ABSTRACT: Nonobstructive azoospermia (NOA) is a severe and heterogeneous form of male factor infertility caused by dysfunction of spermatogenesis. Although various factors are well defined in the disruption of spermatogenesis, not all aspects due to the heterogeneity of the disorder have been determined yet. In this review, we focus on the recent findings and summarize the current data on epigenetic mechanisms such as DNA methylation and different metabolites produced during methylation and demethylation and various types of small noncoding RNAs involved in the pathogenesis of different groups of NOA.

Source: Asian Journal of Andrology

DOI: 10.4103/aja202463

Authors: Sezgin Gunes, Asli Metin Mahmutoglu, Neslihan Hekim

Institutions: Ondokuz Mayıs University, Yozgat Bozok Üniversitesi

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $711